Coding

Part:BBa_K4825000

Designed by: Chen Simiao   Group: iGEM23_GreatBay-SCIE   (2023-10-11)


tHMG1

"HMG1, 3-hydroxy-3-methylglutaryl-CoA reductase, is the endogenous gene in yeast. It can catalyze the conversion from hydroxy-3-methylglutaryl-CoA (HMG-CoA) to mevalonate (MVA). By accumulating MVA through the over expression of tHMG1, MVA pathway is expressed more efficiently, and the yield of isopentenyl pyrophosphate (IPP) and dimethylallyl pyrophosphate (DMAPP) would increase, which are both precursors of pinene, hence the yield of pinene can be increased. "

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Usage and Biology

the endogenous gene in yeast. It can catalyze the conversion from hydroxy-3-methylglutaryl-CoA (HMG-CoA) to mevalonate (MVA).


Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    INCOMPATIBLE WITH RFC[25]
    Illegal NgoMIV site found at 1456
  • 1000
    COMPATIBLE WITH RFC[1000]


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Parameters
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